Back to search

Article

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

2022-06-07

Abstract excerpt

<title>Abstract</title> <p>The mannose-6-phosphate (M6P) biosynthetic pathway for lysosome biogenesis has been studied for decades and is considered a well-understood topic. However, whether this pathway is regulated remains an open question. In a genome-wide CRISPR/Cas9 knockout screen, we discovered TMEM251 as the first regulator of the M6P modification. Deleting TMEM251 caused mistargeting of most lysosomal en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2a8abc61-8c25-561d-882e-6f8c5d896bad
DOI
10.21203/rs.3.rs-1716559/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathwayDOI 10.21203/rs.3.rs-1716559/v1
The lysosomal storage disorders mucolipidosis type II, type III alpha/beta, and type III gamma: Update onGNPTABandGNPTGmutationsSemantic proximity
TFEB-depletion rescues TMEM106B-related myelin defects in zebrafishSemantic proximity
A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stressSemantic proximity
The SHDRA syndrome associated gene TMEM260 encodes a protein-specific O-mannosyltransferaseSemantic proximity
Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasisSemantic proximity
The Versatile Gasdermin Family: Their Function and Roles in DiseasesSemantic proximity
Roles of FAM134B in diseases from the perspectives of organelle membrane morphogenesis and cellular homeostasis.Semantic proximity
Structure and mechanism of the human TMEM260 O-mannosyltransferaseSemantic proximity
The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity.Semantic proximity
Cytosolic Peptide: N-Glycanase (NGLY1)-from Basic Biology to Genetic Disorder, NGLY1 Deficiency.Semantic proximity
The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency.Semantic proximity
ER-associated degradation relying on protein O-mannosylationSemantic proximity
Select a neighboring publication to make it the new centre.