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Article

Impact of pre-imputation SNP-filtering on genotype imputation results.

BMC genetics - 12 Aug 2014

Roshyara Nab Raj, Kirsten Holger, Horn Katrin, Ahnert Peter, Scholz Markus

Abstract excerpt

BACKGROUND: Imputation of partially missing or unobserved genotypes is an indispensable tool for SNP data analyses. However, research and understanding of the impact of initial SNP-data quality control on imputation results is still limited. In this paper, we aim to evaluate the effect of different strategies of pre-imputation quality filtering on the performance of the widely used imputation algorithms MaCH and...

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Identifiers

PMID: 25112433
DOI: 10.1186/s12863-014-0088-5
PMCID: PMC4236550

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