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Article

False positive findings during genome-wide association studies with imputation: influence of allele frequency and imputation accuracy.

Human molecular genetics - 17 Dec 2021

Zhang Zhihui, Xiao Xiangjun, Zhou Wen, Zhu Dakai, Amos Christopher I

Abstract excerpt

Genotype imputation is widely used in genetic studies to boost the power of GWAS, to combine multiple studies for meta-analysis and to perform fine mapping. With advances of imputation tools and large reference panels, genotype imputation has become mature and accurate. However, the uncertain nature of imputed genotypes can cause bias in the downstream analysis. Many studies have compared the performance of...

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Identifiers

PMID: 34368847
DOI: 10.1093/hmg/ddab203
PMCID: PMC8682785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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