Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.

Molecular diagnosis & therapy - 1 Oct 2016

Skrzypczak-Zielinska Marzena, Borun Pawel, Bartkowiak-Kaczmarek Anna, Zakerska-Banaszak Oliwia, Walczak Michal, Dobrowolska Agnieszka, Kurzawski Mateusz, Waszak Malgorzata, Lipinski Daniel, Plawski Andrzej, Slomski Ryszard

Abstract excerpt

Thiopurine methyltransferase (TPMT) and inosine triphosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs: azathioprine and 6-mercaptopurine, used in the treatment of leukemia or inflammatory bowel diseases (IBD). The activity in these enzymes correlates with the genetic polymorphism of the TPMT and ITPA genes, respectively, which determines an individual reaction and dosing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azathioprine
Share to Genotyping Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammatory Bowel Diseases

Share to Mercaptopurine

Share to Methyltransferases

Share to Nucleic Acid Amplification Techniques

Share to Pharmacogenomic Testing

Share to Pyrophosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 27307154
DOI: 10.1007/s40291-016-0217-0
PMCID: PMC5021755

Genes

TPMT
ITPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs.PMID 27307154Read ↗

High-resolution melting analysis of the TPMT gene: a study in the Polish population.Semantic proximity Read ↗

Development and validation of a rapid and reliable method for TPMT genotyping using real-time PCR.Semantic proximity Read ↗

A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

Nomenclature for alleles of the thiopurine methyltransferase gene.Semantic proximity Read ↗

TPMT gene polymorphisms (c.238G>C, c.460G>A and c.719A>G) in a healthy Venezuelan population.Semantic proximity Read ↗

Validation of new allele-specific real-time PCR system for thiopurine methyltransferase genotyping in Korean population.Semantic proximity Read ↗

High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.Semantic proximity Read ↗

Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.Semantic proximity Read ↗

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.Semantic proximity Read ↗

Pharmacogenetics of Thiopurines in Inflammatory Bowel DiseaseSemantic proximity Read ↗

Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.