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Development and validation of a rapid and reliable method for TPMT genotyping using real-time PCR.

Clinical laboratory - 1 Jan 2012

Lorenz Marion, Weise Alexander, Prause Stefan, Klemm Marco, Eidens Moritz, Luchi Massimiliano, Forst Thomas, Pfützner Andreas, Weber Matthias M

Abstract excerpt

BACKGROUND: It is widely accepted that many medications exhibit inter-individual variability in their efficacy and toxicity due to polymorphisms in genes encoding drug-metabolising enzymes. One of the most often cited examples in this context is thiopurine S-methyltransferase (TPMT) polymorphism. TPMT is a phase 2 detoxification enzyme that catalyzes the S-methylation of thiopurine drugs such as thioguanine and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23163112

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Development and validation of a rapid and reliable method for TPMT genotyping using real-time PCR.PMID 23163112Read ↗

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