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Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.

Basic & clinical pharmacology & toxicology - 1 Jan 2021

Zimdahl Kahlin Anna, Helander Sara, Wennerstrand Patricia, Vikingsson Svante, Mårtensson Lars-Göran, Appell Malin Lindqvist

Abstract excerpt

The discovery and implementation of thiopurine methyltransferase (TPMT) pharmacogenetics has been a success story and has reduced the suffering from serious adverse reactions during thiopurine treatment of childhood leukaemia and inflammatory bowel disease. This MiniReview summarizes four studies included in Dr Zimdahl Kahlin's doctoral thesis as well as the current knowledge on this field of research. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32865889
DOI: 10.1111/bcpt.13483
PMCID: PMC7821157

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