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Article

TPMT gene polymorphisms (c.238G>C, c.460G>A and c.719A>G) in a healthy Venezuelan population.

Pharmacogenomics - 1 Mar 2023

Mora Yuselin, Villegas Cecilia, Mora Yamile M, Moreno Nancy

Abstract excerpt

Background: The presence of polymorphisms in the TPMT gene is associated with adverse effects in patients treated with standard doses of thiopurine drugs. Scientific evidence recognizes significant ethnic differences in their frequencies and how their early identification can prevent clinical complications. Methods: 150 healthy residents of Aragua, Venezuela were enrolled. The SNPs c.460G>A and c.719A>G were...

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PMID: 36946340
DOI: 10.2217/pgs-2022-0187

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