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Article

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.

Advances in medical sciences - 1 Mar 2016

Steponaitiene Ruta, Kupcinskas Juozas, Survilaite Santa, Varkalaite Greta, Jonaitis Laimas, Kiudelis Gediminas, Denapiene Goda, Valantinas Jonas, Skieceviciene Jurgita, Kupcinskas Limas

Abstract excerpt

PURPOSE: Inter-individual thiopurine metabolism variability can influence treatment outcomes in inflammatory bowel disease (IBD) patients. Genetic polymorphisms in thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) were linked with toxicity of azathioprine (AZA). The aim of the study was to investigate frequencies of TPMT and ITPA polymorphisms in Lithuanian IBD patients and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26674571
DOI: 10.1016/j.advms.2015.09.008

Genes

TPMT
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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