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Article

MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.

Nucleic acids research - 14 Oct 2016

Santolini Marc, Sakakibara Iori, Gauthier Morgane, Ribas-Aulinas Francesc, Takahashi Hirotaka, Sawasaki Tatsuya, Mouly Vincent, Concordet Jean-Paul, Defossez Pierre-Antoine, Hakim Vincent, Maire Pascal

Abstract excerpt

Myogenic regulatory factors of the MyoD family have the ability to reprogram differentiated cells toward a myogenic fate. In this study, we demonstrate that Six1 or Six4 are required for the reprogramming by MyoD of mouse embryonic fibroblasts (MEFs). Using microarray experiments, we found 761 genes under the control of both Six and MyoD. Using MyoD ChIPseq data and a genome-wide search for Six1/4 MEF3 binding...

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Identifiers

PMID: 27302134
DOI: 10.1093/nar/gkw512
PMCID: PMC5062961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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