Article
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia.
Blood - 23 Jul 2015
Guièze Romain, Wu Catherine J
Abstract excerpt
Defining features of chronic lymphocytic leukemia (CLL) are not only its immunophenotype of CD19(+)CD5(+)CD23(+)sIgdim expressing clonal mature B cells but also its highly variable clinical course. In recent years, advances in massively parallel sequencing technologies have led to rapid progress in our understanding of the CLL genome and epigenome. Overall, these studies have clearly demarcated not only the vast...
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