Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.

doi:10.1371/journal.pone.0018208

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Article

Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.

PloS one - 5 Apr 2011

Jang Yangsoo, Waterworth Dawn, Lee Jong-Eun, Song Kijoung, Kim Sujin, Kim Hyo-Soo, Park Kyung Woo, Cho Hyun-Jai, Oh Il-Young, Park Jeong Euy, Lee Bok-Soo, Ku Hyo Jeong, Shin Dong-Jik, Lee Jong Ho, Jee Sun Ha, Han Bok-Ghee, Jang Hye-Yoon, Cho Eun-Young, Vallance Patrick, Whittaker John, Cardon Lon, Mooser Vincent

Abstract excerpt

BACKGROUND: The Asia-specific PLA2G7 994G-T transversion leads to V279F substitution within the lipoprotein-associated phospholipase-A2 (Lp-PLA₂) and to absence of enzyme activity in plasma. This variant offers a unique natural experiment to assess the role of Lp-PLA₂ in the pathogenesis of coronary artery disease (CAD) in humans. Given conflicting results from mostly small studies, a large two-stage case-control...

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PMID: 21490708
DOI: 10.1371/journal.pone.0018208
PMCID: PMC3071750

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