Article
IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent.
Science immunology - 21 May 2021
Hardman Clare S, Chen Yi-Ling, Salimi Maryam, Nahler Janina, Corridoni Daniele, Jagielowicz Marta, Fonseka Chathuranga L, Johnson David, Repapi Emmanouela, Cousins David J, Barlow Jillian L, McKenzie Andrew N J, Simmons Alison, Ogg Graham
Abstract excerpt
Cutaneous group 2 innate lymphoid cells (ILC2) are spatially and epigenetically poised to respond to barrier compromise and associated immunological threats. ILC2, lacking rearranged antigen-specific receptors, are primarily activated by damage-associated cytokines and respond with type 2 cytokine production. To investigate ILC2 potential for direct sensing of skin pathogens and allergens, we performed RNA...
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