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Article

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

PLoS genetics - 1 Nov 2008

Choy Edwin, Yelensky Roman, Bonakdar Sasha, Plenge Robert M, Saxena Richa, De Jager Philip L, Shaw Stanley Y, Wolfish Cara S, Slavik Jacqueline M, Cotsapas Chris, Rivas Manuel, Dermitzakis Emmanouil T, Cahir-McFarland Ellen, Kieff Elliott, Hafler David, Daly Mark J, Altshuler David

Abstract excerpt

Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and responses to drugs and radiation. In the course of attempting to map genes for drug response using 269 LCLs from the International HapMap Project, we evaluated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19043577
DOI: 10.1371/journal.pgen.1000287
PMCID: PMC2583954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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