Article
Cancer-related somatic mutations alter adenosine A1 receptor pharmacology-A focus on mutations in the loops and C-terminus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2022
Wang Xuesong, Jespers Willem, de Waal Just J, Wolff Kim A N, van Uden Liedeke, IJzerman Adriaan P, van Westen Gerard J P, Heitman Laura H
Abstract excerpt
G protein-coupled receptors (GPCRs) are known to be involved in tumor progression and metastasis. The adenosine A1 receptor (A1 AR) has been detected to be over-expressed in various cancer cell lines. However, the role of A1 AR in tumor development is not yet well characterized. A series of A1 AR mutations were identified in the Cancer Genome Atlas from cancer patient samples. In this study, we have investigated...
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