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Inherited cardiac diseases, pluripotent stem cells, and genome editing combined—the past, present, and future

30 Oct 2019

Abstract excerpt

Research on mechanisms underlying monogenic cardiac diseases such as primary arrhythmias and cardiomyopathies has until recently been hampered by inherent limitations of heterologous cell systems, where mutant genes are expressed in noncardiac cells, and physiological differences between humans and experimental animals. Human-induced pluripotent stem cells (hiPSCs) have proven to be a game changer by providing...

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PMID: 31664757
DOI: 10.1002/stem.3110

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