Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.

doi:10.1038/ncomms11845

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Article

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.

Nature communications - 13 Jun 2016

Hoefflin Rouven, Lahrmann Bernd, Warsow Gregor, Hübschmann Daniel, Spath Cathleen, Walter Britta, Chen Xin, Hofer Luisa, Macher-Goeppinger Stephan, Tolstov Yanis, Korzeniewski Nina, Duensing Anette, Grüllich Carsten, Jäger Dirk, Perner Sven, Schönberg Gita, Nyarangi-Dix Joanne, Isaac Sanjay, Hatiboglu Gencay, Teber Dogu, Hadaschik Boris, Pahernik Sascha, Roth Wilfried, Eils Roland, Schlesner Matthias, Sültmann Holger, Hohenfellner Markus, Grabe Niels, Duensing Stefan

Abstract excerpt

Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell carcinoma (ccRCC). Here we address the question whether ITH increases with malignant progression and can hence be exploited as a prognostic marker. Unexpectedly, precision quantitative image analysis reveals that the degree of functional ITH is virtually...

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PMID: 27291893
DOI: 10.1038/ncomms11845
PMCID: PMC4910022

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