Article

Spatial patterns of tumour growth impact clonal diversification: computational modelling and evidence in the TRACERx Renal study

2021-02-19

Abstract excerpt

<title>Abstract</title> <p>Intra-tumour genetic heterogeneity (ITH) fuels cancer evolution. The role of clonal diversity and genetic complexity in the progression of clear-cell renal cell carcinomas (ccRCCs) has been characterised, but the ability to predict clinically relevant evolutionary trajectories remains limited. Here, towards enhancing this ability, we investigated spatial features of clonal diversificati...

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Literature Corpus work: 9f485cb8-7890-5e67-a294-6a3fd96b12cb
DOI: 10.21203/rs.3.rs-244285/v1

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