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Article

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

BMC genomics - 10 Jun 2016

Ligthart Symen, Vaez Ahmad, Hsu Yi-Hsiang, Stolk Ronald, Uitterlinden André G, Hofman Albert, Alizadeh Behrooz Z, Franco Oscar H, Dehghan Abbas

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism. RESULTS: In a bivariate GWAS, we combined summary statistics of published GWAS on CRP (n = 66,185) and...

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Topics

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Share to C-Reactive Protein
Share to Cholesterol, HDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Inflammation

Share to Lipid Metabolism

Share to Multifactorial Inheritance

Share to Quantitative Trait Loci

Share to Triglycerides

Source

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Identifiers

PMID: 27286809
DOI: 10.1186/s12864-016-2712-4
PMCID: PMC4901478

Genes

CRP
FDFT1
PCCB
FTO
CTSB
STAG1

Provenance

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