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Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease

1 Dec 2018

Abstract excerpt

BACKGROUND: Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits. METHODS: We performed a bivariate GWAS to discover novel loci...

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PMID: 30525989
DOI: 10.1161/circgen.118.002239

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