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Article

Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.

PloS one - 1 Jan 2015

Ligthart Symen, de Vries Paul S, Uitterlinden André G, Hofman Albert, Franco Oscar H, Chasman Daniel I, Dehghan Abbas

Abstract excerpt

Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic background of inflammation and cardiometabolic phenotypes using published genome-wide association studies (GWAS). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25768928
DOI: 10.1371/journal.pone.0118859
PMCID: PMC4358943

Genes

CRP
APOC1
FTO
GCKR
PABPC4
TMEM18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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