Article

Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease

2018-05-11

Abstract excerpt

<h4>Background</h4> Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independently of one another. Joint GWAS for two related phenotypes can lead to a higher-powered analysis to detect variants contributing to both traits. <h4>Methods and Results</h4> We performed a bivariate GWA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9611b6cd-7332-5e1d-b8b1-74b611de6143
DOI: 10.1101/319848

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery diseaseDOI 10.1101/319848Read

Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery DiseaseSemantic proximity Read

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.Semantic proximity Read

A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traitsSemantic proximity Read

Discovery and refinement of loci associated with lipid levels.Semantic proximity Read

Large-scale association analysis identifies new risk loci for coronary artery disease.Semantic proximity Read

Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease.Semantic proximity Read

The breadth and impact of the Global Lipids Genetics ConsortiumSemantic proximity Read

GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations.Semantic proximity Read

Genetics of coronary artery disease in the post-GWAS era.Semantic proximity Read

Integrative genetic analysis reveals shared genetic architecture underlying coronary artery disease, CT-Defined coronary atherosclerosis, and cardiometabolic risk factors.Semantic proximity Read

Association of Genetically Predicted Levels of Circulating Blood Lipids with Coronary Artery Disease IncidenceSemantic proximity Read

Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels.Semantic proximity Read