Article
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease.
European journal of human genetics : EJHG - 1 Feb 2021
Ruotsalainen Sanni E, Partanen Juulia J, Cichonska Anna, Lin Jake, Benner Christian, Surakka Ida, Reeve Mary Pat, Palta Priit, Salmi Marko, Jalkanen Sirpa, Ahola-Olli Ari, Palotie Aarno, Salomaa Veikko, Daly Mark J, Pirinen Matti, Ripatti Samuli, Koskela Jukka
Abstract excerpt
Multivariate methods are known to increase the statistical power to detect associations in the case of shared genetic basis between phenotypes. They have, however, lacked essential analytic tools to follow-up and understand the biology underlying these associations. We developed a novel computational workflow for multivariate GWAS follow-up analyses, including fine-mapping and identification of the subset of...
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