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Article

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia.

CNS neuroscience & therapeutics - 1 Sept 2016

Meng Hai-Lan, Li Xiao-Xi, Chen Yan-Ting, Yu Lin-Jie, Zhang He, Lao Jia-Min, Zhang Xin, Xu Yun

Abstract excerpt

AIMS: This study explored sFasL expression in neurons and the potential role of neuronal sFasL in modulating the microglial phenotypes. METHODS: In vivo, middle cerebral artery occlusion (MCAO) was induced in both FasL-mutant (gld) and wild-type (wt) mice. In vitro, primary cortical neuron or microglia or coculture from wt/gld mice was subjected to oxygen glucose deprivation (OGD). sFasL level in the supernatant...

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Identifiers

PMID: 27283206
DOI: 10.1111/cns.12575
PMCID: PMC6492913

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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