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Article

Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke.

Brain, behavior, and immunity - 1 Jan 2012

Niu Feng-nan, Zhang Xin, Hu Xiao-ming, Chen Jun, Chang Lei-lei, Li Jing-wei, Liu Zhuo, Cao Wangsen, Xu Yun

Abstract excerpt

Inflammation is an important contributing mechanism in ischemic brain injury. The current study elucidates a previously unexplored role of Fas ligand (FasL) in post-stroke inflammatory responses that is independent of its well-known effect in triggering apoptosis. Focal cerebral ischemia was induced for 2 h by right middle cerebral artery occlusion (MCAO) in FasL mutant (gld) and wild-type mice. FasL mutation...

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Identifiers

PMID: 21802508
DOI: 10.1016/j.bbi.2011.07.235

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