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Article

MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling.

Proceedings of the National Academy of Sciences of the United States of America - 6 Feb 2018

Dzieran Johanna, Rodriguez Garcia Aida, Westermark Ulrica Kristina, Henley Aine Brigette, Eyre Sánchez Elena, Träger Catarina, Johansson Henrik Johan, Lehtiö Janne, Arsenian-Henriksson Marie

Abstract excerpt

Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic nervous system with clinical behavior ranging from spontaneous regression to poorly differentiated tumors and metastasis. MYCN is amplified in 20% of cases and correlates with an undifferentiated, aggressive phenotype and poor prognosis. Estrogen receptor alpha (ERα) and the nerve growth factor (NGF) receptors TrkA and p75NTR are...

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Source

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Identifiers

PMID: 29374092
DOI: 10.1073/pnas.1710901115
PMCID: PMC5819392

Genes

NGF
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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