Article

LEDGF/p75 is Required for an Efficient DNA Damage Response

2021-05-07

Abstract excerpt

<title>Abstract</title> <p> BackgroundLens epithelium derived growth factor splice variant of 75 kDa (LEDGF/p75), is overexpressed in different solid cancers and cancer cell lines and various autoinflammatory diseases. Due to its ability to bind chromatin, it acts as a transcriptional co-activator and promotes anti-apoptotic signalling pathways that lead to increased tumour aggressiveness and resistance to chemo...

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Literature Corpus work: fc96087c-95cb-54dc-a661-d15f424716b5
DOI: 10.21203/rs.3.rs-111961/v2

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