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Article

Negative auto-regulators trap p53 in their web

6 Jan 2017

Abstract excerpt

The transcriptional factor p53 activates the expression of a myriad of target genes involving a complicated signalling network, resulting in various cellular outcomes, such as growth arrest, senescence, apoptosis, and metabolic changes, and leading to consequent suppression of tumour growth and progression. Because of the profoundly adverse effect of p53 on growth and proliferation of cancer cells, several...

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PMID: 28069666
DOI: 10.1093/jmcb/mjx001

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