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Article

The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer.

PLoS computational biology - 1 Feb 2014

Acuner Ozbabacan Saliha Ece, Gursoy Attila, Nussinov Ruth, Keskin Ozlem

Abstract excerpt

Interleukin-1 (IL-1) is a large cytokine family closely related to innate immunity and inflammation. IL-1 proteins are key players in signaling pathways such as apoptosis, TLR, MAPK, NLR and NF-κB. The IL-1 pathway is also associated with cancer, and chronic inflammation increases the risk of tum...

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Identifiers

PMID: 24550720
DOI: 10.1371/journal.pcbi.1003470
PMCID: PMC3923659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24550720-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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