Article
A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data.
Biometrics - 1 Mar 2017
Fu Rong, Wang Pei, Ma Weiping, Taguchi Ayumu, Wong Chee-Hong, Zhang Qing, Gazdar Adi, Hanash Samir M, Zhou Qinghua, Zhong Hua, Feng Ziding
Abstract excerpt
In this article, we propose a new statistical method-MutRSeq-for detecting differentially expressed single nucleotide variants (SNVs) based on RNA-seq data. Specifically, we focus on nonsynonymous mutations and employ a hierarchical likelihood approach to jointly model observed mutation events as well as read count measurements from RNA-seq experiments. We then introduce a likelihood ratio-based test statistic,...
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