Article
DrGaP: a powerful tool for identifying driver genes and pathways in cancer sequencing studies.
American journal of human genetics - 5 Sept 2013
Hua Xing, Xu Haiming, Yang Yaning, Zhu Jun, Liu Pengyuan, Lu Yan
Abstract excerpt
Cancers are caused by the accumulation of genomic alterations. Driver mutations are required for the cancer phenotype, whereas passenger mutations are irrelevant to tumor development and accumulate through DNA replication. A major challenge facing the field of cancer genome sequencing is to identify cancer-associated genes with mutations that drive the cancer phenotype. Here, we describe a powerful and flexible...
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