Article

Combined analysis of genome sequencing and RNA-motifs reveals novel damaging non-coding mutations in human tumors

2017-10-09

Abstract excerpt

A major challenge in cancer research is to determine the biological and clinical significance of somatic mutations in non-coding regions. This has been studied in terms of recurrence, functional impact, and association to individual regulatory sites, but the combinatorial contribution of mutations to common RNA regulatory motifs has not been explored. We developed a new method, MIRA, to perform the first comprehen...

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Literature Corpus work: ff88596a-7bae-5a28-886d-e26437350d87
DOI: 10.1101/200188

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