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Article

The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth

6 Jun 2016

Abstract excerpt

The complement system (C1q/C3) is a key mediator of synaptic pruning during normal development. HIV inappropriately induces C1q and C3 production in the brain, and reduces neuronal complement inhibition. HIV may thus alter neural connectivity in the developing brain by excessively targeting synapses for elimination. The resultant pattern of neuronal injury may fundamentally alter neurodevelopmental and cognitive...

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PMID: 27273074
DOI: 10.1007/s13365-016-0460-5

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