Article
A Nonlinear Model for Gene-Based Gene-Environment Interaction.
International journal of molecular sciences - 4 Jun 2016
Sa Jian, Liu Xu, He Tao, Liu Guifen, Cui Yuehua
Abstract excerpt
A vast amount of literature has confirmed the role of gene-environment (G×E) interaction in the etiology of complex human diseases. Traditional methods are predominantly focused on the analysis of interaction between a single nucleotide polymorphism (SNP) and an environmental variable. Given that genes are the functional units, it is crucial to understand how gene effects (rather than single SNP effects) are...
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