Article
Integrative analysis of gene-environment interactions under a multi-response partially linear varying coefficient model.
Statistics in medicine - 10 Dec 2014
Wu Cen, Cui Yuehua, Ma Shuangge
Abstract excerpt
Consider the integrative analysis of genetic data with multiple correlated response variables. The goal is to identify important gene-environment (G × E) interactions along with main gene and environment effects that are associated with the responses. The homogeneity and heterogeneity models can be adopted to describe the genetic basis of multiple responses. To accommodate possible nonlinear effects of some...
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