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Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

29 Jan 2015

Abstract excerpt

Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition. The function of the DNA helicase encoded by WRN, the gene responsible for WS, has been studied extensively. WRN helicase is involved in the maintenance of chromosome integrity through DNA replication, repair, and...

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PMID: 25688260
DOI: 10.3389/fgene.2015.00010

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