Article

Mechanical unloading attenuates mechanoflammation and restores the SOX9/RUNX2 axis in IL-1β-sensitized murine articular chondrocytes

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>Objective This study aimed to investigate whether targeted mechanical unloading can disrupt the mechanoflammatory feed-forward loop and intrinsically restore cellular homeostasis by rescuing the SOX9/RUNX2 transcriptional axis. Methods An in vitro model using primary murine articular chondrocytes was established. Cells were treated with either 10 ng/mL interleukin-1β (IL-1β) alone or...

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Literature Corpus work: f032f105-d23b-5da1-bb98-fae6ea4d562f
DOI: 10.21203/rs.3.rs-10282387/v1

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