Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces

Abstract excerpt

KEY POINTS: microRNAs (miRs) are small non-coding molecules that regulate post-transcriptional target gene expression. miRs are involved in regulating cellular activities in response to mechanical loading in all physiological systems, although it is largely unknown whether this response differs with increasing magnitudes of load. miR-221, miR-222, miR-21-5p and miR-27a-5p were significantly increased in ex vivo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to MicroRNA in disease regulation
• Share to Osteoarthritis Treatment and Mechanisms
• Share to Tendon Structure and Treatment