Article
TGF-β2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft - 1 Mar 2015
Das R, Timur U T, Edip S, Haak E, Wruck C, Weinans H, Jahr H
Abstract excerpt
Culturing chondrocytes under oxygen tension closely resembling their in vivo environment has been shown to have positive effects on matrix synthesis. In redifferentiation of expanded chondrocytes, hypoxia increased collagen type II expression. However, the mechanism by which hypoxia enhances redifferentiation is still unknown. We employed novel bioreactor technology to investigate the role of TGF-β, a growth...
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