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Article

A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression.

Cellular and molecular neurobiology - 16 Oct 2025

Zhang Shu, Chen Yiji, Xu Wenshen, Yan Danfang, Chen Meiqin, Zheng Jiayi, Huang Liming

Abstract excerpt

The O6-methylguanine-DNA methyltransferase (MGMT) plays a significant role in the pathogenesis and progression of glioma. Numerous enhancer variants, including those within the MGMT gene region and adjacent gene regions, have been found to be associated with cancer development and progression. We investigated the significance of enhancer variants located in the intergenic spacer far from the MGMT gene in relation...

Read the complete abstract on PubMed

Topics

Humans
Glioma
Male
Disease Progression
Female
Genetic Predisposition to Disease
DNA Modification Methylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Suppressor Proteins

Middle Aged

DNA Repair Enzymes

Enhancer Elements, Genetic

Polymorphism, Single Nucleotide

Brain Neoplasms

Adult

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41099912
DOI: 10.1007/s10571-025-01605-6
PMCID: PMC12532543

Genes

MGMT
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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