Article
The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2011
Leng Shuguang, Bernauer Amanda M, Hong Chibo, Do Kieu C, Yingling Christin M, Flores Kristina G, Tessema Mathewos, Tellez Carmen S, Willink Randall P, Burki Elizabeth A, Picchi Maria A, Stidley Christine A, Prados Michael D, Costello Joseph F, Gilliland Frank D, Crowell Richard E, Belinsky Steven A
Abstract excerpt
PURPOSE: To address the association between sequence variants within the MGMT (O(6)-methylguanine-DNA methyltransferase) promoter-enhancer region and methylation of MGMT in premalignant lesions from smokers and lung adenocarcinomas, their biological effects on gene regulation, and targeting MGMT for therapy. EXPERIMENTAL DESIGN: Single nucleotide polymorphisms (SNP) identified through sequencing a 1.9 kb fragment...
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