Article
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2010
Levine A Joan, Figueiredo Jane C, Lee Won, Poynter Jenny N, Conti David, Duggan David J, Campbell Peter T, Newcomb Polly, Martinez Maria Elena, Hopper John L, Le Marchand Loic, Baron John A, Limburg Paul J, Ulrich Cornelia M, Haile Robert W
Abstract excerpt
BACKGROUND: The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk. METHODS: We used a tagSNP approach to comprehensively evaluate associations between variation in the MTHFR gene and colorectal cancer risk using a large family-based case-control study of 1,750 population-based...
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