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Article

Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.

Molecular and cellular biology - 1 Jan 2000

Song S, Grenfell T Z, Garfield S, Erikson R L, Lee K S

Abstract excerpt

Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In addition to the kinase domain, polo kinases have a strikingly conserved sequence in the noncatalytic C-terminal domain, termed the polo box. Here we show that the budding-yeast polo kinase Cdc5, when fused to green fluorescent protein and expressed under its endogenous promoter, localizes at spindle poles and the mother...

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Identifiers

PMID: 10594031
DOI: 10.1128/MCB.20.1.286-298.2000
PMCID: PMC85084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.PMID 10594031Read ↗

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