Article
Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis.
Acta oncologica (Stockholm, Sweden) - 1 Apr 2020
Nunes Luís, Aasebø Kristine, Mathot Lucy, Ljungström Viktor, Edqvist Per-Henrik, Sundström Magnus, Dragomir Anca, Pfeiffer Per, Ameur Adam, Ponten Fredrik, Mezheyeuski Artur, Sorbye Halfdan, Sjöblom Tobias, Glimelius Bengt
Abstract excerpt
Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from clinical trials or hospital-based patient groups. The aim was to explore if other mutations in mCRC differ in prevalence between these cohorts in relation to mismatch repair status and primary...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Bone Neoplasms
- Brain Neoplasms
- Cohort Studies
- Colorectal Neoplasms
- Female
- Genes, Neoplasm