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Article

Prevalence and prognostic relevance of BrafV600E mutation in colorectal carcinomas from Kashmir (North India) valley.

Mutagenesis - 17 Sept 2018

Eachkoti Rafiqa, Farooq Sanah, Syeed Sheikh Imran, Wani Hilal Ahmed, Majid Sabhiya, Pampori Mohd Rafiq

Abstract excerpt

Molecular studies have implicated mutant B-type Raf kinase (BRAFMut) of MAP-kinase signalling pathway in the pathogenesis of several cancers including colorectal cancer. Recently, the prognostic and therapeutic relevance of the most frequent BRAFV600E mutation also has been highlighted in colorectal carcinomas (CRC). Thus, the aim of this study was to investigate the prevalence of BRAFV600E mutation and to...

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PMID: 29800258
DOI: 10.1093/mutage/gey008

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BRAF

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