Article
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.
Nature communications - 8 Apr 2020
Laurien Lucie, Nagata Masahiro, Schünke Hannah, Delanghe Tom, Wiederstein Janica L, Kumari Snehlata, Schwarzer Robin, Corona Teresa, Krüger Marcus, Bertrand Mathieu J M, Kondylis Vangelis, Pasparakis Manolis
Abstract excerpt
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induces apoptosis and necroptosis, however the mechanisms and phosphorylation events regulating RIPK1-dependent cell death signaling remain poorly understood. Here we show...
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