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Article

Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes.

Endocrinology - 1 Mar 2011

Liao Xiao-Hui, Di Cosmo Caterina, Dumitrescu Alexandra M, Hernandez Arturo, Van Sande Jacqueline, St Germain Donald L, Weiss Roy E, Galton Valerie Anne, Refetoff Samuel

Abstract excerpt

Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5'-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent each of the 5'-deiodinases (D1, D2) contributes to the serum TH abnormalities of the Mct8KO by generating mice with...

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PMID: 21285310
DOI: 10.1210/en.2010-0900
PMCID: PMC3040057

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