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Article

Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes.

The Journal of reproduction and development - 1 Jan 2013

Lee Ah Reum, Kishigami Satoshi, Amano Tomoko, Matsumoto Kazuya, Wakayama Teruhiko, Hosoi Yoshihiko

Abstract excerpt

Postovulatory mammalian oocyte developmental potential decreases with aging in vivo and in vitro. Aging oocytes typically show cellular fragmentation and chromosome scattering with an abnormally shaped spindle over time. Previously, it was shown that histone acetylation in the mouse oocyte increa...

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Identifiers

PMID: 23474603
DOI: 10.1262/jrd.2012-171
PMCID: PMC3934134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23474603-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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