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Article

Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility

8 May 2009

Abstract excerpt

BACKGROUND: In humans, normal healthy children are regularly produced through fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes and spermatozoa, especially when aged oocytes are fertilized by fresh or senescent spermatozoa, will not only affect the rate of fertilization and pre- and post-implantation embryo development but also the life of the offspring. As many failures...

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PMID: 19429634
DOI: 10.1093/humupd/dmp014

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