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Nuclear Origin of Aging-Associated Meiotic Defects in Senescence-Accelerated Mice1

20 Oct 2004

Abstract excerpt

Factors of both cytoplasmic and nuclear origin regulate metaphase chromosome alignment and spindle checkpoint during mitosis. Most aneuploidies associated with maternal aging are believed to derive from nondisjunction and meiotic errors, such as aberrations in spindle formation and chromosome alignment at meiosis I. Senescence-accelerated mice (SAM) exhibit aging-associated meiotic defects, specifically...

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PMID: 15269097
DOI: 10.1095/biolreprod.104.028985

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