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Article

A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator

3 Oct 2016

Abstract excerpt

BACKGROUND: The ubiquitin-editing cytosolic enzyme A20, the major negative regulator of toll-like receptor (TLR)-mediated cellular inflammatory responses, has tight genetic linkage with systemic sclerosis (SSc). Because recent studies implicate endogenous ligand-driven TLR signaling in SSc pathogenesis, we sought to investigate the regulation, role and mechanism of action of A20 in skin fibroblasts. METHOD: A20...

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PMID: 27716397
DOI: 10.1186/s13075-016-1118-7

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